The advent of genomic sequencing technologies has revolutionized our understanding of disease transmission, pathogen evolution, drug resistance, and virulence. Pathogens can quickly adapt to new environments and treatments, making it critical to understand the underlying genetic changes that drive this process. The Michigan Infectious Disease Genomics (MIDGE) Center features three projects - viruses, bacteria, and fungi - unified by a common theme of identifying pathogen determinants of epidemic success and by a common approach that combines genomic surveillance, functional genomics, and high-throughput phenotyping assays